HCID 10826647、化合物 → HCID 15480019、化合物
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][CH2:9][C:8]([C:12]([O:14]C)=[O:13])=[CH:7][C:6]=2[CH:16]=1>CO.C1COCC1.[OH-].[Na+]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][CH2:10][CH2:9][C:8]([C:12]([OH:14])=[O:13])=[CH:7][C:6]=2[CH:16]=1参加物
5
実験手順
A mixture of methyl 2-bromo-6,7-dihydro-5H-benzocyclohepten-8-carboxylate (1.0 g) in methanol (25 ml), THF (25 ml) and 1N NaOH (18 ml) was refluxed for 1 hour. The solvent was concentrated, acidified using 1N HCl, and extracted with ethyl acetate. The organic layer was washed with water and brine, and dried over MgSO4. The solvent was evaporated in vacuo to give 2-bromo-6,7-dihydro-5H-benzocyclohepten-8-carboxylic acid (0.95 g) as colorless prisms.
後処理
- temperaturewas refluxed for 1 hour
- concentrationThe solvent was concentrated
- extractionextracted with ethyl acetate
- washThe organic layer was washed with water and brine
- dry with materialdried over MgSO4
- customThe solvent was evaporated in vacuo
出典と根拠
- ORDレコード
- ord-7b2fc606ea234a04be7919173fe174d0
- 出典データセット
- uspto-grants-2002_04
- 特許番号
- US06376536B1
反応ノート
読み込み中…