Isopropanol → Diisopropyl (S)-(-)-malate

HRID 843280ノート

反応式

HRID 843280 の反応式
[C:1]([OH:9])(=[O:8])[C@H:2]([CH2:4][C:5]([OH:7])=[O:6])[OH:3].[C:10]1(C)[CH:15]=CC(S(O)(=O)=O)=C[CH:11]=1.[CH:21](O)([CH3:23])[CH3:22]>>[C:1]([O:9][CH:21]([CH3:23])[CH3:22])(=[O:8])[C@H:2]([CH2:4][C:5]([O:7][CH:10]([CH3:15])[CH3:11])=[O:6])[OH:3]

参加物

4

反応物 3

HCID 3776IsopropanolHCID 6101p-Toluenesulfonic acidHCID 222656L-Malic Acid

生成物 1

HCID 11333435Diisopropyl (S)-(-)-malate

実験手順

(S)-malic acid was dissolved in isopropanol and p-toluenesulphonic acid (cat) was added and stirred at room temperature for 24 h. The reaction mixture was concentrated and distilled to give (S)-diisopropyl malate as colorless liquid. The residual material in the distillation flask was dissolved in EtOH and processed as above. Distillation afforded additional diester, raising the total yield.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. distillationdistilled

出典と根拠

ORDレコード
ord-b40b84d951c54a0092c8ce12e5f00cd7
出典データセット
uspto-grants-2002_04
特許番号
US06376683B1

反応ノート

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