Pyruvic Acid → 2-(2,3,4-Trifluoroanilino)propionic acid
反応式
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[N+:10]([O-])=O.[C:13]([OH:18])(=[O:17])[C:14]([CH3:16])=O>CC(O)C.[Pd]>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[NH:10][CH:14]([CH3:16])[C:13]([OH:18])=[O:17]参加物
5
反応条件
- 温度
- 40 °C
実験手順
2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.09 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.
後処理
- filtrationAfter filtering off Pd—C
- concentrationthe obtained filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-000aaf21ce6b430c92135e59c6c72ea3
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087778B2
反応ノート
読み込み中…