Oxalyl chloride → 2-(6-Methoxynaphthalen-2-yl)propanoyl chloride

HRID 844513ノート

反応式

HRID 844513 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14](O)=[O:15])[CH:7]=[CH:6]2.C(Cl)(=O)C([Cl:21])=O>CN(C=O)C.C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([Cl:21])=[O:15])[CH:7]=[CH:6]2

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 156391Naproxen

生成物 1

HCID 54916922-(6-Methoxynaphthalen-2-yl)propanoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of (S)-6-methoxy-α-methyl-2-naphthaleneacetic acid (23.09 g) and THF (41 mL) is agitated until dissolution is achieved. Oxalyl chloride (17.5 mL) is added to the flask followed by DMF (3 drops) and heptanes (50 mL). The mixture is stirred for approximately 2 hours. The resulting slurry is filtered, washed with heptane (15 mL) and aspirated for 3 minutes and vacuum dried to give 17.44 g.

後処理

  1. stirringThe mixture is stirred for approximately 2 hours
  2. filtrationThe resulting slurry is filtered
  3. washwashed with heptane (15 mL)
  4. customvacuum dried
  5. customto give 17.44 g

出典と根拠

ORDレコード
ord-1b9ecbecac02427fbba42a1a7b4a338d
出典データセット
uspto-grants-2002_04
特許番号
US06380388B1

反応ノート

読み込み中…