Hydrogen Peroxide → (+)-Sclareol oxide
反応式
[CH3:1][C@@:2]12[C@@H:11]([CH2:12][CH2:13][C@@:14]([OH:18])([CH:16]=C)C)[C@@:10](O)([CH3:19])[CH2:9][CH2:8][C@H:7]1[C:6]([CH3:22])([CH3:21])[CH2:5][CH2:4][CH2:3]2.O=[O+][O-].OO>>[CH3:16][C:14]1[O:18][C@@:2]2([CH3:1])[C@@H:11]([C@:10]3([CH3:19])[C@@H:5]([CH2:4][CH2:3]2)[C:6]([CH3:21])([CH3:22])[CH2:7][CH2:8][CH2:9]3)[CH2:12][CH:13]=1参加物
4
実験手順
Sclareol is oxidised with ozone, followed by treatment with alkaline hydrogen peroxide to give sclareol oxide. The sclareol oxide is then oxidised with an organic hydroperoxide, preferably tert-butyl hydroperoxide, to give 12-acetyl-norlabdane oxide. The 12-acetyl-norlabdane oxide is converted to 12-acetoxy-norlabdane oxide by oxidation with an organic peracid, preferably peracetic acid. The 12-acetoxy-norlabdane oxide is then reduced to norlabdane oxide with sodium borohydride in the presence of a transition metal salt. The reaction scheme of EP 0882191A may be represented as follows:
出典と根拠
- ORDレコード
- ord-a407cabda3864302b15b12f89c1edef1