Hydrochloric Acid → trans-2-p-Cyanophenyl-5-pentyl-1,4-dioxane

HRID 845011ノート

反応式

HRID 845011 の反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][O:12][C@H:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:10][O:9]2)=[CH:4][CH:3]=1.[C:19](C#N)#[N:20].N1C=CC=CC=1.Cl>CN1CCCC1=O>[C:19]([C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][O:12][C@H:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:10][O:9]2)=[CH:4][CH:3]=1)#[N:20]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 1049PyridineHCID 9999CyanogenHCID 86742258trans-2-p-Bromophenyl-5-pentyl-1,4-dioxane

生成物 1

HCID 86742257trans-2-p-Cyanophenyl-5-pentyl-1,4-dioxane

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

実験手順

A mixture of 31.3 g. trans-2-p-bromophenyl-5-pentyl-1,4-dioxane, 10 g. Cu2 (CN)2, 120 ml. pyridine and 60 ml. N-methylpyrrolidone is heated for 2 hours to 150°. One cools, adds thereto a solution of 120 g. FeCl3.6H2O in 600 ml. 20% hydrochloric acid, heats to 70° for 1.5 hours, while stirring. Works up as usu 1 and obtains trans-2-p-cyanophenyl-5-pentyl-1,4-dioxane.

後処理

  1. additionA mixture of 31.3 g
  2. additionadds

出典と根拠

ORDレコード
ord-7710397969054b5c91874984c6919d8f
出典データセット
uspto-grants-1988_07
特許番号
US04755323

反応ノート

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