1-(2-Hydroxyethyl)piperazine → 3-[4-(2-Hydroxyethyl)piperazin-1-yl]propan-1-ol

HRID 845019ノート

反応式

HRID 845019 の反応式
[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[CH2:10]([OH:13])[CH:11]=[CH2:12].[OH-].[Na+].C(=O)([O-])[O-].[K+].[K+]>O>[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([CH2:12][CH2:11][CH2:10][OH:13])[CH2:6][CH2:5]1

参加物

6

反応物 4

HCID 76771-(2-Hydroxyethyl)piperazineHCID 7858Allyl AlcoholHCID 11430Potassium CarbonateHCID 14798Sodium Hydroxide

生成物 1

HCID 3425243-[4-(2-Hydroxyethyl)piperazin-1-yl]propan-1-ol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1-(2-hydroxyethyl)-piperazine, 26 grams, freshly distilled allyl alcohol, 36 g and sodium hydroxide, 8 g are heated to 118°-120° C. for 36 hours. The viscous reaction mixture is taken up into 250 ml water, and solid potassium carbonate is added to saturate the warmed solution. A yellow oil, the product, rises to the top. It is extracted with tetrahydrofuran, the solvent evaporated, the residue dissolved in ethanol, the solution filtered, and the ethanol evaporated under vacuum to a thick oil, which solidifies on standing to give the isolated product, [I], above.

後処理

  1. additionis added
  2. concentrationto saturate the warmed solution
  3. extractionIt is extracted with tetrahydrofuran
  4. customthe solvent evaporated
  5. dissolutionthe residue dissolved in ethanol
  6. filtrationthe solution filtered
  7. customthe ethanol evaporated under vacuum to a thick oil, which
  8. customto give the isolated product, [I]

出典と根拠

ORDレコード
ord-dde797f15e3247bea2cbf830a800653a
出典データセット
uspto-grants-1988_07
特許番号
US04755515

反応ノート

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