Hydroquinone → Methyl acrylamidoglycolate methyl ether

HRID 845874ノート

反応式

HRID 845874 の反応式
[C:1]([NH:5][CH:6]([OH:11])[C:7]([O:9][CH3:10])=[O:8])(=[O:4])[CH:2]=[CH2:3].CO.[CH3:14]OC.C1(C=CC(O)=CC=1)O.C(N(CC(O)=O)CC(O)=O)CN(CC(O)=O)CC(O)=O>>[CH3:14][O:11][CH:6]([NH:5][C:1](=[O:4])[CH:2]=[CH2:3])[C:7]([O:9][CH3:10])=[O:8]

参加物

6

反応物 5

HCID 785HydroquinoneHCID 887MethanolHCID 6049Ethylenediaminetetraacetic AcidHCID 8254Dimethyl EtherHCID 157058Methyl 2-hydroxy-2-(1-oxo-2-propenylamino)acetate

生成物 1

HCID 156893Methyl acrylamidoglycolate methyl ether収率 85%

実験手順

Methyl acrylamidoglycolate, as prepared in Example I, in the amount of 100 parts (0.63 mole) is combined with 200 parts of methanol (6.3 moles), 0.10 parts of the methyl ether of hydroquinone and 0.005 part of ethylene-diamine tetraacetic acid and 5.0 parts of a 40% aqueous solution of paratoluenesulfonic acid is added as catalyst. The reaction mixture is heated for 4 hours at reflux temperature and then cooled and filtered. Vacuum stripping of the methanol results in crystallization of the product. An 85% yield of methyl acrylamidoglycolate methyl ether is obtained.

後処理

  1. additionis added as catalyst
  2. temperatureThe reaction mixture is heated for 4 hours
  3. temperatureat reflux temperature
  4. temperaturecooled
  5. filtrationfiltered
  6. customVacuum stripping of the methanol results in crystallization of the product

出典と根拠

ORDレコード
ord-63962f70461247b29c2f55b66540cc30
出典データセット
uspto-grants-1988_07
特許番号
US04760168

反応ノート

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