Acetone Cyanohydrin → (3S)-3-hydroxy-3-phenylpropanenitrile
反応式
[CH2:1]1[O:9][C@@H:2]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.CC(C)(O)[C:12]#[N:13].C(N(CC)CC)C>O1CCCC1>[C:3]1([C@@H:2]([OH:9])[CH2:1][C:12]#[N:13])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1参加物
5
実験手順
A mixture of 40.0 g of (R)-styrene oxide, 31.12 g of acetone cyanohydrin, 36.96 g of triethylamine, and 150 ml of tetrahydrofuran was heated at reflux for 18 hours. The reaction mixture was cooled, concentrated in vacuo, diluted with 200 ml of 2N potassium hydroxide, and extracted with diethyl ether. The ether extracts were combined, dried over magnesium sulfate, and concentrated in vacuo providing 34.3 g of the title intermediate.
後処理
- temperaturewas heated
- temperatureat reflux for 18 hours
- temperatureThe reaction mixture was cooled
- concentrationconcentrated in vacuo
- additiondiluted with 200 ml of 2N potassium hydroxide
- extractionextracted with diethyl ether
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-031d64a9ec0c47989fe335f90f58eb3c
- 出典データセット
- uspto-grants-1992_08
- 特許番号
- US05136078
反応ノート
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