Methanol → 4-Chloro-2-methoxybenzothiazole

HRID 847795

反応式

HRID 847795 の反応式
Br[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1.[OH-:12].[Na+].[CH3:14]O>O>[CH3:14][O:12][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:5]=2[N:6]=1

参加物

5

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 771782-Bromo-4-chlorobenzothiazole

生成物 1

HCID 41419694-Chloro-2-methoxybenzothiazole収率 93.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-Bromo-4-chlorobenzothiazole (6.21 g, 0.025 mole) and 94% sodium hydroxide (1.57 g, 0.037 mole) were added to methanol (100 c.c.), and the mixture was heated under reflux for 30 minutes. After cooling, water (100 c.c.) was added to the reaction solution, followed by ice-cooling. The deposited crystals were filtered and washed with water to obtain 4.68 g of 2-methoxy-4-chlorobenzothiazole. Yield 93.8%, purity 99.3%, m.p. 55°-57° C.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. temperatureAfter cooling
  4. temperaturecooling
  5. filtrationThe deposited crystals were filtered
  6. washwashed with water

出典と根拠

ORDレコード
ord-6e26b00862f84353ab12bbfba02506a2
出典データセット
uspto-grants-1981_10
特許番号
US04293702

関連ノート

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