Methanol → 3-(2-Quinazolinylmethoxy)benzyl chloride

HRID 849000ノート

反応式

HRID 849000 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16]O.CO.C(Cl)(Cl)[Cl:24]>O=S(Cl)Cl>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[N:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16][Cl:24]

参加物

5

反応物 3

HCID 887MethanolHCID 6212ChloroformHCID 543359633-(2-Quinazolinylmethoxy)benzyl alcohol

生成物 1

HCID 540176783-(2-Quinazolinylmethoxy)benzyl chloride

試薬・触媒・溶媒 1

HCID 24386Thionyl Chloride溶媒

実験手順

To a solution of 1.00 g (3.76 mmol) of 3-(2-quinazolinylmethoxy)benzyl alcohol in 10 ml of CHCl3, 0.5 ml of SOCl2 was added, followed by stirring at room temperature for 15 hours. A small amount of MeOH was added to the reaction mixture and the solvents were distilled off under reduced pressure, whereby 1.08 g of 3-(2-quinazolinylmethoxy) benzyl chloride were obtained as white powder.

後処理

  1. distillationthe solvents were distilled off under reduced pressure

出典と根拠

ORDレコード
ord-6dbce0b12e824656bbaed1017af58bd2
出典データセット
uspto-grants-2000_01
特許番号
US06011033

反応ノート

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