Sodium Hydroxide → (+-)-2-Amino-2-ethylhex-4-en-1-ol

HRID 850

反応式

HRID 850 の反応式
[NH2:1][C:2]([CH2:12][CH3:13])([CH2:8][CH:9]=[CH:10][CH3:11])[C:3](OCC)=[O:4].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>C1COCC1>[NH2:1][C:2]([CH2:12][CH3:13])([CH2:8][CH:9]=[CH:10][CH3:11])[CH2:3][OH:4]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 54508860(+-)-Ethyl 2-amino-2-ethylhex-4-enoate

生成物 1

HCID 54018667(+-)-2-Amino-2-ethylhex-4-en-1-ol収率 32.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of the product from step (d) (116.7 g) in THF (100 ml) was added to a 1M solution of lithium aluminium hydride in THF (800 ml) at about 0° C. When addition was complete, the mixture was stirred overnight at room temperature, then 50% w/v aqu. NaOH (200 ml) was added. The organic phase was separated, washed with brine, dried and evaporated in vacuo. The residue was distilled to give the desired product as an oil (29.3 g). 1H NMR consistent with the proposed structure.

後処理

  1. additionWhen addition
  2. customThe organic phase was separated
  3. washwashed with brine
  4. customdried
  5. customevaporated in vacuo
  6. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-8bc8a5b260b5493c8773ed6d142bea7c
出典データセット
uspto-grants-1998_03
特許番号
US05723458

関連ノート

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