Sodium Hydroxide → (+-)-2-Amino-2-ethylhex-4-en-1-ol
反応式
[NH2:1][C:2]([CH2:12][CH3:13])([CH2:8][CH:9]=[CH:10][CH3:11])[C:3](OCC)=[O:4].[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>C1COCC1>[NH2:1][C:2]([CH2:12][CH3:13])([CH2:8][CH:9]=[CH:10][CH3:11])[CH2:3][OH:4]参加物
5
実験手順
A solution of the product from step (d) (116.7 g) in THF (100 ml) was added to a 1M solution of lithium aluminium hydride in THF (800 ml) at about 0° C. When addition was complete, the mixture was stirred overnight at room temperature, then 50% w/v aqu. NaOH (200 ml) was added. The organic phase was separated, washed with brine, dried and evaporated in vacuo. The residue was distilled to give the desired product as an oil (29.3 g). 1H NMR consistent with the proposed structure.
後処理
- additionWhen addition
- customThe organic phase was separated
- washwashed with brine
- customdried
- customevaporated in vacuo
- distillationThe residue was distilled
出典と根拠
- ORDレコード
- ord-8bc8a5b260b5493c8773ed6d142bea7c
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723458
反応ノート
読み込み中…