Phenethyl bromide → 5-(3-Methoxyphenyl)-1-(2-phenylethyl)-1,2,3,6-tetrahydropyridine

HRID 851139ノート

反応式

HRID 851139 の反応式
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:10]2[CH2:11][NH:12][CH2:13][CH2:14][CH:15]=2)[CH:7]=[CH:8][CH:9]=1.C(=O)([O-])[O-].[Na+].[Na+].[CH2:22](Br)[CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC(C)=O>[CH3:2][O:3][C:4]1[CH:5]=[C:6]([C:10]2[CH2:11][N:12]([CH2:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:13][CH2:14][CH:15]=2)[CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 7666Phenethyl bromideHCID 10340Sodium CarbonateHCID 130667493-(3-Methoxyphenyl)-1,2,5,6-tetrahydropyridine hydrochloride

生成物 1

HCID 132342035-(3-Methoxyphenyl)-1-(2-phenylethyl)-1,2,3,6-tetrahydropyridine

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of 5 g of 3-(3-methoxyphenyl)-1,2,5,6-tetrahydropyridine hydrochloride, 100 ml of acetone, 7 g of sodium carbonate and 3.5 ml of phenethyl bromide was refluxed for 16 hours and was filtered. The filtrate was evaporated to dryness and the residue was chromatographed over silica gel. The elution with a 7-3 cyclohexane-ethyl acetate mixture yielded 6.2 g of 3-(3-methoxyphenyl)-1-phenethyl-1,2,5,6-tetrahydropyridine.

後処理

  1. temperaturewas refluxed for 16 hours
  2. filtrationwas filtered
  3. customThe filtrate was evaporated to dryness
  4. customthe residue was chromatographed over silica gel
  5. washThe elution with a 7-3 cyclohexane-ethyl acetate mixture

出典と根拠

ORDレコード
ord-bffbb67ecc56421c96d29c5cb46e51be
出典データセット
uspto-grants-1983_05
特許番号
US04382942

反応ノート

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