Hydrochloric Acid → 6-Carboxy-7-methoxy-4-(indol-5-yloxy)quinoline

HRID 853499ノート

反応式

HRID 853499 の反応式
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][CH:9]=[C:8]2[O:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][CH:22]=[CH:21]2)=[O:4].[OH-].[Li+].Cl>O1CCCC1>[C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[O:15][CH3:16])[N:11]=[CH:10][CH:9]=[C:8]2[O:17][C:18]1[CH:19]=[C:20]2[C:24](=[CH:25][CH:26]=1)[NH:23][CH:22]=[CH:21]2)([OH:4])=[O:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 229366056-Methoxycarbonyl-7-methoxy-4-(5-indolyloxy)quinoline

生成物 1

HCID 229369786-Carboxy-7-methoxy-4-(indol-5-yloxy)quinoline収率 72.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

After dissolving 6-methoxycarbonyl-7-methoxy-4-(indol-5-yloxy)quinoline (400 mg) in tetrahydrofuran (5 ml), a 1.5N aqueous lithium hydroxide solution (2.5 ml) was added and the mixture was stirred at room temperature for 3 hours. The reaction solution was adjusted to pH 4 with IN aqueous hydrochloric acid, and the precipitated crystals were filtered out and washed with ethyl acetate to obtain the title compound (280 mg).

後処理

  1. filtrationthe precipitated crystals were filtered out
  2. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-2a5f5a16dc7148d7944d779bc2e097fc
出典データセット
uspto-grants-2007_08
特許番号
US07253286B2

反応ノート

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