Hydrochloric Acid → 4-Isopropyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid

HRID 854549ノート

反応式

HRID 854549 の反応式
C([O:3][C:4]([C:6]1[S:10][C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[N:8][C:7]=1[CH:21]([CH3:23])[CH3:22])=[O:5])C.[OH-].[Na+].Cl>C1COCC1>[CH:21]([C:7]1[N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:19])([F:20])[F:18])=[CH:13][CH:12]=2)[S:10][C:6]=1[C:4]([OH:5])=[O:3])([CH3:23])[CH3:22]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 587658244-Isopropyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid ethyl ester

生成物 1

HCID 589340934-Isopropyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

To a solution of 4-isopropyl-2-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid ethyl ester (0.62 g, 1.80 mmol) in THF (10 mL) is added 5M NaOH (3.5 mL, 17.50 mmol). The mixture is heated at 70° C. for 12 h. Upon cooling to RT, the mixture is acidified with 5M HCl and extracted with EtOAc. The organics are washed with water and brine, and dried with MgSO4. After concentration, the title compound is obtained (0.46 g, 81%). The material is used without further purification.

後処理

  1. temperatureUpon cooling to RT
  2. extractionextracted with EtOAc
  3. washThe organics are washed with water and brine
  4. dry with materialdried with MgSO4
  5. concentrationAfter concentration

出典と根拠

ORDレコード
ord-fb53eea34e1a4278b9c22820ee9cae64
出典データセット
uspto-grants-2007_08
特許番号
US07259175B2

反応ノート

読み込み中…