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Triethylamine → 3-(2-Methyl-4-{[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-carbamoyl}-phenyl)-propionic acid ethyl ester

HRID 854564
ノート
印刷プレビュー

反応式

HRID 854564 の反応式
[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:17][NH2:18].[C:19]([CH2:22][CH2:23][C:24]1[CH:32]=[CH:31][C:27]([C:28]([OH:30])=O)=[CH:26][C:25]=1[CH3:33])([OH:21])=[O:20].[CH2:34](N(CC)CC)[CH3:35].CCN=C=NCCCN(C)C>CN(C1C=CN=CC=1)C.C(Cl)Cl.C(Cl)(Cl)Cl>[CH2:34]([O:21][C:19](=[O:20])[CH2:22][CH2:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](=[O:30])[NH:18][CH2:17][C:3]2[N:4]=[C:5]([C:7]3[CH:8]=[CH:9][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:11][CH:12]=3)[O:6][C:2]=2[CH3:1])=[CH:26][C:25]=1[CH3:33])[CH3:35]
参加物実験手順後処理出典と根拠反応ノート

参加物

8

反応物 4

HCID 8471TriethylamineHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 58765787C-[5-Methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-methylamineHCID 694730814-(2-Carboxy-ethyl)-3-methyl-benzoic acid

生成物 1

HCID 694707913-(2-Methyl-4-{[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-carbamoyl}-phenyl)-propionic acid ethyl ester

試薬・触媒・溶媒

3
HCID 142844-(Dimethylamino)pyridine触媒HCID 6212Chloroform溶媒HCID 6344Dichloromethane溶媒

実験手順

To a mixture of C-[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-yl]-methylamine (0.2 g, 0.78 mmol) and 4-(2-carboxy-ethyl)-3-methyl-benzoic acid (0.173 g, 0.78 mmol) and DMAP (5 mg) in methylene chloride (5 mL) are added triethyl amin (0.12 mL, 0.86 mml) and EDCI (150 mg, 0.78 mmol) at room temperature. After stirred for 3 hrs, diluted with chloroform, washed with water, 1N HCl and 2 N NaOH aqueous. Concentration and column chromatography on silica gel gave the title compound (240 mg).

後処理

  1. washwashed with water, 1N HCl and 2 N NaOH aqueous
  2. concentrationConcentration and column chromatography on silica gel

出典と根拠

ORDレコード
ord-e7239e7ef55f4c18bc06ec2520623b1b
出典データセット
uspto-grants-2007_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07259175B2

反応ノート

読み込み中…

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