Aluminium lithium hydride → HCID 58979003、化合物

HRID 854581

反応式

HRID 854581 の反応式
C[O:2][C:3](=O)[CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:12]=[N:13][C:14]([Cl:17])=[CH:15][CH:16]=2)[O:8][C:9]=1[CH3:10].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[Cl:17][C:14]1[N:13]=[CH:12][C:11]([C:7]2[O:8][C:9]([CH3:10])=[C:5]([CH2:4][CH2:3][OH:2])[N:6]=2)=[CH:16][CH:15]=1

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 58765666[2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester

生成物 1

HCID 58979003HCID 58979003、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of [2-(6-Chloro-pyridin-3-yl)-5-methyl-oxazol-4-yl]-acetic acid methyl ester (4.0 g, 15 mmol) from step B in THF (50 mL) is added a solution of lithium aluminum hydride in THF (1.0 M, 12.5 mL, 12.5 mmol) at 0° C. After 1 hr, the reaction is quenched by water and sodium hydroxide, filtered, concentrated. The crude material is used for the next step.

後処理

  1. customthe reaction is quenched by water and sodium hydroxide
  2. filtrationfiltered
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-af3bb7310b2d40ba982ffbe4852d0f55
出典データセット
uspto-grants-2007_08
特許番号
US07259175B2

関連ノート

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