4-Aminothiophenol → HCID 22938738、化合物

HRID 856660ノート

反応式

HRID 856660 の反応式
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]2[C:10]=1[CH2:11]O.[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([SH:20])=[CH:16][CH:15]=1.[OH-].[Na+]>Cl>[NH2:13][C:14]1[CH:19]=[CH:18][C:17]([S:20][CH2:11][C:10]2[N:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]3=[N:3][C:2]=2[CH3:1])=[CH:16][CH:15]=1

参加物

5

反応物 3

HCID 145104-AminothiophenolHCID 14798Sodium HydroxideHCID 7060539(2-methylimidazo[1,2-a]pyridin-3-yl)methanol

生成物 1

HCID 22938738HCID 22938738、化合物収率 22.2%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

Under nitrogen atmosphere, to a suspension of aluminum lithium hydride (1.6 g) in THF (100 ml) was added dropwise a solution of ethyl 2-methylimidazo[1,2-a]pyridine-3-carboxylate (8.56 g) in THF (100 ml) at 0° C. under nitrogen atmosphere. The mixture was stirred for 1 hour at 0° C., water (1.6 ml), 15% aqueous solution of sodium hydroxide (1.6 ml) and water (4.8 ml) were sequentially and slowly added dropwise to the solution, and the mixture was stirred for 2 hours at room temperature. To the reaction solution was added magnesium sulfate, and the precipitates were removed by filtration. The mixture was concentrated under reduced pressure, to give 2-methylimidazo[1,2-a]pyridine-3-methanol (6.45 g) as pale yellow amorphous. A mixture of 2-methylimidazo[1,2-a]pyridine-3-methanol (1 g) and 4-aminothiophenol (0.65 g) in concentrated hydrochloric acid (10 ml) was stirred for 18 hours at room temperature. 8N aqueous solution of sodium hydroxide was added to adjust pH to 10 at 0° C. and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over magnesium sulfate and concentrated under reduced pressure. The obtained residue was separated and purified by column chromatography (ethanol:ethyl acetate 1:4), to give 3-(4-aminophenylthiomethyl)-2-methylimidazo[1,2-a]pyridine (311 mg) as colorless crystals.

後処理

  1. customat 0° C.
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe obtained residue was separated
  7. custompurified by column chromatography (ethanol:ethyl acetate 1:4)

出典と根拠

ORDレコード
ord-c56f7a404e4744048910b2a24ee57ce3
出典データセット
uspto-grants-2007_08
特許番号
US07262185B2

反応ノート

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