Thionyl Chloride → 2-(chloromethyl)-1-methyl-1H-imidazole hydrochloride

HRID 856761

反応式

HRID 856761 の反応式
O[CH2:2][C:3]1[N:4]([CH3:8])[CH:5]=[CH:6][N:7]=1.S(Cl)([Cl:11])=O>>[ClH:11].[Cl:11][CH2:2][C:3]1[N:4]([CH3:8])[CH:5]=[CH:6][N:7]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 573612(1-methyl-1H-imidazol-2-yl)methanol

生成物 1

HCID 27954062-(chloromethyl)-1-methyl-1H-imidazole hydrochloride

反応条件

温度
90 °C

実験手順

To 2-hydroxymethyl-1-methylimidazole (874 mg) was added thionyl chloride (10 ml) at 0° C., and the mixture was heated for 30 minutes under nitrogen atmosphere at 90° C. The mixture was allowed to be at room temperature. The solvent was distilled off under reduced pressure and the obtained residue was recrystallized from ethyl acetate, to give 2-chloromethyl-1-methylimidazole hydrochloride (1.15 g) as brown crystals.

後処理

  1. customto be at room temperature
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe obtained residue was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-55507ce07af64445b0909f7af6bd6c7e
出典データセット
uspto-grants-2007_08
特許番号
US07262185B2

関連ノート

読み込み中…