Ethyl chloroacetate → 1-(3-Iodophenyl)-2,4-imidazolidinedione

HRID 857103ノート

反応式

HRID 857103 の反応式
[I:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]([NH2:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[H-].[Na+].Cl[CH2:15][C:16](OCC)=[O:17]>CN(C=O)C>[I:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:15][C:16](=[O:17])[NH:11][C:9]2=[O:10])[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 7751Ethyl chloroacetateHCID 24758Sodium hydrideHCID 21867173(3-iodophenyl)urea

生成物 1

HCID 218671771-(3-Iodophenyl)-2,4-imidazolidinedione

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 3-iodophenylurea (2.1 g) in DMF (20 ml) was treated with sodium hydride (60% oil dispersion; 640 mg), followed by ethyl chloroacetate (0.93 ml) and the mixture was stirred for 5 h. The mixture was partitioned between EtOAc and 2M HCl and the organic solution was washed with NaHCO3, brine, dried and evaporated to dryness to give the title compound (2.08 g) ES+ve 303(MH)+.

後処理

  1. customThe mixture was partitioned between EtOAc and 2M HCl
  2. washthe organic solution was washed with NaHCO3, brine
  3. customdried
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-b5db57e3fd204cacb9fdda816d0786a8
出典データセット
uspto-grants-2006_12
特許番号
US07144908B2

反応ノート

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