反応式
[C:1]([C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7])#[N:2].C[Si]([C:16]([Si](C)(C)C)(C([O-])=O)[C:17]([O-:19])=[O:18])(C)C.[Li][CH2:28][CH2:29][CH2:30]C.[C:32]([OH:38])([C:34](F)(F)F)=[O:33]>CCOCC.C(OC(C)=C)(=O)C>[C:1]([C:3]1[CH:4]=[C:5]([C:6](=[O:7])[CH2:16][C:17]([OH:19])=[O:18])[CH:9]=[CH:10][CH:11]=1)#[N:2].[CH3:30][C:29]1([CH3:28])[O:7][C:6]([C:5]2[CH:4]=[C:3]([CH:11]=[CH:10][CH:9]=2)[C:1]#[N:2])=[CH:34][C:32](=[O:33])[O:38]1参加物
8
反応物 4
生成物 2
試薬・触媒・溶媒 2
実験手順
The 3-(3-cyano-phenyl)-3-oxo-propionic acid was prepared from 3-cyanobenzoyl chloride (828 mg, 5 mmol) and bis(trimethylsilyl)malonate (2.56 mL, 10 mmol) with n-BuLi (1.6M in hexane, 6.25 mL) in ether at −60° C. to 0° C. according to general procedure H (method c2). The crude material (1.04 g) was transformed into the title compound by stirring in isopropenyl acetate and TFA according to general procedure J (method a). Obtained as a light yellow solid (0.8 g).
出典と根拠
- ORDレコード
- ord-6bb19336f5d24d2b93e1d1e4aa7c53af
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07151098B2
関連ノート
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