Diethyl Ether → Pyridine-4-amidine hydrochloride
反応式
[Na].[C:2]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)#[N:3].[Cl-:10].[NH4+:11].C(OCC)C>CO>[ClH:10].[C:2]([C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1)(=[NH:11])[NH2:3]参加物
6
実験手順
To a solution of sodium (0.23 g) in methanol (40 ml) was added 4-cyanopyridine (10.62 g) at room temperature. Stirring was continued for 6 h followed by the addition of ammoniumchloride (5.9 g) and stirring was continued for another 10 h. Then diethylether (120 ml) was added and the precipitate was filtered off after 30 min and washed once with diethylether (20 ml). The product was dried under high vacuum. 4-Amidino-pyridine hydrochloride (14.95 g) was obtained as a white powder.
後処理
- stirringstirring
- waitwas continued for another 10 h
- filtrationthe precipitate was filtered off after 30 min
- washwashed once with diethylether (20 ml)
- customThe product was dried under high vacuum
出典と根拠
- ORDレコード
- ord-f98f5a335bf343b985a425cce2db865f
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07091201B2
反応ノート
読み込み中…