Ammonium formate → 9-(1-Acetyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl)-3-(2-methyl-pyrimidin-5-yl)-nonanoic acid ethyl ester

HRID 860091ノート

反応式

HRID 860091 の反応式
[CH2:1]([O:3][C:4](=[O:32])[CH2:5][CH:6]([C:25]1[CH:26]=[N:27][C:28]([CH3:31])=[N:29][CH:30]=1)[CH:7]=[CH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[N:18]=[C:17]2[N:19]([C:22](=[O:24])[CH3:23])[CH2:20][CH2:21][C:16]2=[CH:15][CH:14]=1)[CH3:2].C([O-])=O.[NH4+]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:32])[CH2:5][CH:6]([C:25]1[CH:26]=[N:27][C:28]([CH3:31])=[N:29][CH:30]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[N:18]=[C:17]2[N:19]([C:22](=[O:24])[CH3:23])[CH2:20][CH2:21][C:16]2=[CH:15][CH:14]=1)[CH3:2]

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 696665499-(1-Acetyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl)-3-(2-methyl-pyrimidin-5-yl)-non-4-enoic acid ethyl ester

生成物 1

HCID 587655219-(1-Acetyl-2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl)-3-(2-methyl-pyrimidin-5-yl)-nonanoic acid ethyl ester収率 33.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 23-10 (0.150 g, 0.34 mmol), ammonium formate (0.192 g, 3.09 mmol), and 10% Pd/C (0.150 g) in EtOH (25 rnL) was refluxed for 15 minutes. Filtration through celite and evaporative removal of the solvent followed by purification by PCTLC (0–10% MeOH-CHCl3) afforded 0.050 g of 23-11.

後処理

  1. filtrationFiltration through celite
  2. customremoval of the solvent
  3. customfollowed by purification by PCTLC (0–10% MeOH-CHCl3)

出典と根拠

ORDレコード
ord-ac1a33a739b2463388f1beefdab9ded5
出典データセット
uspto-grants-2006_12
特許番号
US07153862B2

反応ノート

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