Sodium Hydroxide → n-(4-Carbamimidoyl-phenyl)-2-phenyl-malonamic acid sodium salt

HRID 860178ノート

反応式

HRID 860178 の反応式
C([O:8][C:9](=[O:29])[CH:10]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:11]([NH:13][C:14]1[CH:19]=[CH:18][C:17]([C:20](=[NH:22])[NH2:21])=[CH:16][CH:15]=1)=[O:12])C1C=CC=CC=1.[OH-].[Na+:31]>C1COCC1>[Na+:31].[C:20]([C:17]1[CH:16]=[CH:15][C:14]([NH:13][C:11](=[O:12])[CH:10]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:9]([O-:29])=[O:8])=[CH:19][CH:18]=1)(=[NH:21])[NH2:22]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10110753HCID 10110753、化合物

生成物 1

HCID 23700157n-(4-Carbamimidoyl-phenyl)-2-phenyl-malonamic acid sodium salt

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

8.26 g (19.5 mmol) of the benzyl ester from example 1 were dissolved in 100 ml THF and stirred overnight with 20 ml 2 M aqueous NaOH. The solvent was removed after filtration, water was added, and the solution extracted with diethyl ether. The aqueous phase was freeze dried and sufficiently pure for further derivatization.

後処理

  1. customThe solvent was removed
  2. filtrationafter filtration, water
  3. additionwas added
  4. extractionthe solution extracted with diethyl ether
  5. customdried and sufficiently pure for further derivatization

出典と根拠

ORDレコード
ord-80021ebbbb5a4ec49a4f9333d7dfcb19
出典データセット
uspto-grants-2006_12
特許番号
US07153876B2

反応ノート

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