Venlafaxine → Desvenlafaxine

HRID 860915

反応式

HRID 860915 の反応式
C(S)CCCCCCCCCCC.[CH3:14][N:15]([CH2:17][CH:18]([C:27]1([OH:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[C:19]1[CH:20]=[CH:21][C:22]([O:25]C)=[CH:23][CH:24]=1)[CH3:16].C([O-])C.[Na+]>>[CH3:14][N:15]([CH2:17][CH:18]([C:27]1([OH:33])[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]1)[C:19]1[CH:20]=[CH:21][C:22]([OH:25])=[CH:23][CH:24]=1)[CH3:16]

参加物

4

反応物 3

HCID 5656VenlafaxineHCID 81951-DodecanethiolHCID 2723922Sodium ethoxide

生成物 1

HCID 125017Desvenlafaxine

反応条件

温度
150 °C

実験手順

Dodecanethiol (69 g), venlafaxine (55 g), and an ethanolic solution of sodium ethanolate (21%, 82 g) are charged to a pressure vessel. The temperature is raised to 150° C. and the reaction mixture is stirred for 2 days. Then the temperature is lowered and the solution is filtered. The pH of the filtrate is adjusted to 9.5 with aqueous hydrogen chloride. The crystals are collected by suction filtration. The cake is washed with ethanol and dried in vacuo.

後処理

  1. filtrationthe solution is filtered
  2. filtrationThe crystals are collected by suction filtration
  3. washThe cake is washed with ethanol
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-1f210c72ef1d4d6dbed5314b68ac8d0c
出典データセット
uspto-grants-2006_12
特許番号
US07154001B2

関連ノート

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