2-Fluorobenzophenone → (2-Fluorophenyl)(phenyl)methanol

HRID 861901

反応式

HRID 861901 の反応式
[F:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>C(O)C>[F:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH:4]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)[OH:5]

参加物

4

反応物 2

HCID 676502-FluorobenzophenoneHCID 4311764Sodium borohydride

生成物 1

HCID 10584252(2-Fluorophenyl)(phenyl)methanol収率 99%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Fluorobenzophenone (15.0 g) is dissolved in ethanol and sodium borohydride (3.8 g) is added in portions and the mixture is stirred for 20 hours. The reacted solution is concentrated under reduced pressure and extracted with chloroform and water to give crude (2-fluorophenyl)phenylmethanol (15.0 g) (quantitative) as colorless liquid.

後処理

  1. concentrationThe reacted solution is concentrated under reduced pressure
  2. extractionextracted with chloroform and water

出典と根拠

ORDレコード
ord-c9141cfb5aeb445e97fcde16004fb780
出典データセット
uspto-grants-1998_02
特許番号
US05716950

関連ノート

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