1,2-Dibromoethane → (2-Bromo-ethyl)-(3-fluorobenzyl)-amine

HRID 8636

反応式

HRID 8636 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][NH2:6].[Br:10][CH2:11][CH2:12]Br.C(=O)([O-])[O-].[Na+].[Na+]>O>[Br:10][CH2:11][CH2:12][NH:6][CH2:5][C:4]1[CH:7]=[CH:8][CH:9]=[C:2]([F:1])[CH:3]=1

参加物

5

反応物 3

HCID 78391,2-DibromoethaneHCID 10340Sodium CarbonateHCID 668533-Fluorobenzylamine

生成物 1

HCID 21983578(2-Bromo-ethyl)-(3-fluorobenzyl)-amine

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Combine 3-fluorobenzylamine (5.0 g, 0.0400 mol), fused sodium acetate (3.28 g, 0.0400 mol) and 1,2-dibromoethane (7.51 g, 0.0400 mol) and reflux for several hours. Pour the mixture into water and add sodium carbonate to create a basic pH. Remove the unreacted 1,2-dibromoethane by distillation. Extract the left-over residue with ether and evaporate to obtain the final, desired compound. The compound can form the hydrochloride salt.

後処理

  1. customRemove the unreacted 1,2-dibromoethane
  2. distillationby distillation
  3. extractionExtract the left-over residue with ether
  4. customevaporate

出典と根拠

ORDレコード
ord-581af56aec3a433e9adb69447c08ffc7
出典データセット
uspto-grants-2006_08
特許番号
US07091199B1

関連ノート

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