tert-Butyl hydroperoxide → HCID 19050660、化合物

HRID 863759

反応式

HRID 863759 の反応式
[CH3:1][N:2]([C:9]([C:11]1[C:12]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[N:13][O:14][C:15]=1[CH2:16][C:17]1[N:22]=[C:21]([O:23][CH3:24])[CH:20]=[C:19]([O:25][CH3:26])[N:18]=1)=[O:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C([O:37]O)(C)(C)C>C(#N)C.[CH-]=O.[CH-]=O.[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[C-]#[O+].[Co].[Co+2]>[CH3:1][N:2]([C:9]([C:11]1[C:12]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[N:13][O:14][C:15]=1[C:16]([C:17]1[N:22]=[C:21]([O:23][CH3:24])[CH:20]=[C:19]([O:25][CH3:26])[N:18]=1)=[O:37])=[O:10])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 6410tert-Butyl hydroperoxide2 回HCID 19050670HCID 19050670、化合物

生成物 1

HCID 19050660HCID 19050660、化合物

試薬・触媒・溶媒 2

HCID 25049Dicobalt Octacarbonyl (stabilized with 1-5% Hexane)触媒HCID 6342Acetonitrile溶媒

実験手順

A solution of 100 mg of N-methyl 3-phenyl-5-(4,6-dimethoxy-2-pyrimidinylmethyl)-4-isoxazolecarboxanilide, 20 mg of dicobalt octacarbonyl, and 1 ml of t-butylhydroperoxide, in 60 ml of acetonitrile is refluxed for 48 hours. An additional 1 ml of t-butylhydroperoxide is added after 12 hrs and 24 hrs. Thin layer chromatography after 48 hrs indicates the presence of starting material and the title compound.

出典と根拠

ORDレコード
ord-776e651b363d4802847ce5c4cfead691
出典データセット
uspto-grants-1996_10
特許番号
US05561101

関連ノート

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