Pyridine → (3-Bromothien-2-yl) (3-methoxyphenyl)methanone oxime

HRID 8641

反応式

HRID 8641 の反応式
[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=O.Cl.[NH2:18][OH:19].N1C=CC=CC=1.C(Cl)Cl>CCCCCC>[Br:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[N:18][OH:19]

参加物

6

反応物 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 443297Hydroxyamine hydrochlorideHCID 21915416(3-Bromothien-2-yl) (3-methoxyphenyl)methanone

生成物 1

HCID 72727313(3-Bromothien-2-yl) (3-methoxyphenyl)methanone oxime収率 87%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

Stir a mixture of (3-bromothiophen-2-yl)-(3-methoxyphenyl)methanone (7 g, 0.024 mol), hydroxylamine hydrochloride (3.09 g, 0.048 mol) and pyridine (40 mL) overnight at room temperature, and then heat the mixture (100° C.–105° C.) for four hours. TLC (DCM) shows that the reaction is complete. Quench the reaction mixture with water and extract with ether (three times). Wash the ether phase with HCl (3N) and water, dry (MgSO4), filter and concentrate to yield an oil that solidifies. Recrystallize the solid from ether:hexane to obtain the title compound (6.4 g, 87% Yield), m.p. 102–103° C.

後処理

  1. temperatureheat the mixture (100° C.–105° C.) for four hours
  2. customQuench the reaction mixture with water
  3. extractionextract with ether (three times)
  4. washWash the ether phase with HCl (3N) and water
  5. dry with materialdry (MgSO4)
  6. filtrationfilter
  7. concentrationconcentrate
  8. customto yield an oil
  9. customRecrystallize the solid from ether

出典と根拠

ORDレコード
ord-6dcbe5d9d92e4048baae54673195caa5
出典データセット
uspto-grants-2006_08
特許番号
US07091199B1

関連ノート

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