Water → 3-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-6-methylpyridine

HRID 865222ノート

反応式

HRID 865222 の反応式
[H-].[Na+].[CH2:3]([OH:9])[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl[C:11]1[C:15]([C:16]2[CH:17]=[N:18][C:19]([CH3:22])=[CH:20][CH:21]=2)=[N:14][S:13][N:12]=1.O>C1COCC1>[CH2:3]([O:9][C:11]1[C:15]([C:16]2[CH:17]=[N:18][C:19]([CH3:22])=[CH:20][CH:21]=2)=[N:14][S:13][N:12]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

参加物

6

反応物 4

HCID 962WaterHCID 81031-HexanolHCID 24758Sodium hydrideHCID 190752683-(3-Chloro-1,2,5-thiadiazol-4-yl)-6-methylpyridine

生成物 1

HCID 190755123-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-6-methylpyridine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Sodium hydride (0.72 g, 15 mmol) was dissolved in dry THF (20 ml) and 1-hexanol (1.53 g, 15 mmol) and a solution of 3-(3-chloro-1,2,5-thiadiazol-4-yl)-6-methylpyridine (1.06 g, 5 mmol) in dry THF (15 ml) was added. The reaction mixture was stirred for 2 h. After addition of water the mixture was extracted with ether, and the ether phase was dried and evaporated. The residue consisted of the crude title compound, which was used without further purification.

後処理

  1. extractionwas extracted with ether
  2. dry with materialthe ether phase was dried
  3. customevaporated
  4. customwas used without further purification

出典と根拠

ORDレコード
ord-08fe69a6a1b44b97a028e278fa690d16
出典データセット
uspto-grants-1996_10
特許番号
US05565475

反応ノート

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