Methanol → Methyl alpha-(2-n-propyl-4-methylaminosulfonylphenoxy)-3,4-methylenedioxyphenylacetate

HRID 865534ノート

反応式

HRID 865534 の反応式
[CH2:1]([C:4]1[CH:24]=[C:23]([S:25]([NH2:28])(=[O:27])=[O:26])[CH:22]=[CH:21][C:5]=1[O:6][CH:7]([C:12]1[CH:17]=[CH:16][C:15]2[O:18][CH2:19][O:20][C:14]=2[CH:13]=1)[C:8]([O:10][CH3:11])=[O:9])[CH2:2][CH3:3].N12CCCN=C1CCCC[CH2:30]2.IC.CO>C1COCC1.CCOC(C)=O>[CH2:1]([C:4]1[CH:24]=[C:23]([S:25]([NH:28][CH3:30])(=[O:26])=[O:27])[CH:22]=[CH:21][C:5]=1[O:6][CH:7]([C:12]1[CH:17]=[CH:16][C:15]2[O:18][CH2:19][O:20][C:14]=2[CH:13]=1)[C:8]([O:10][CH3:11])=[O:9])[CH2:2][CH3:3]

参加物

7

反応物 4

HCID 887MethanolHCID 6328Methyl iodideHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 19080400Methyl alpha-(2-n-propyl-4-aminosulfonyl-phenoxy)-3,4-methylenedioxyphenylacetate

生成物 1

HCID 19080392Methyl alpha-(2-n-propyl-4-methylaminosulfonylphenoxy)-3,4-methylenedioxyphenylacetate収率 7.2%

試薬・触媒・溶媒 2

HCID 8028Tetrahydrofuran溶媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

To a solution of 2.19 g (5.38 mmol) of the product of Step C dissolved in 20 mL of anhydrous THF was added 2.41 mL (16.1 mmol) of 1,8-diazabicyclo[5.4.0]undec-7-ene and the reaction mixture was magnetically stirred under a nitrogen atmosphere for 25 minutes at room temperature. Iodomethane (1.00 mL; 16.1 mmol) was added and the reaction mixture was stirred an additional 15 hours at room temperature. The reaction mixture was diluted with EtOAc and a precipitate formed which was redissolved by addition of methanol. The mixture was further diluted with warm EtOAc (150 mL total), refridgerated overnight and a solid separated which was removed by filtration. The filtrate was evaporated in vacuo and the residue was purified on a silica gel flash chromatography column eluted with 5% EtOAc-CHCl3. Combination of the purified fractions and evaporation in vacuo afforded 0.164 g of the title compound and a number of impure fractions which were reserved for repurification. 1H-NMR (400 MHz, CD3OD, ppm): δ 0.97 (t, J=7.20 Hz, 3H), 1.65-1.77 (m, 2H), 2.48 (s, 3H), 2.74 (t, J=7.20 Hz, 2H), 3.71 (s, 3H), 5.87 (s, 1H), 5.98 (s, 2H), 6.85 (d, J=8.00 Hz, 1H), 6.96 (d, J=8.80 Hz, 1H), 7.04 (d, J=1.60 Hz, 1H), 7.07 (dd, J=1.60, 8.00 Hz, 1H), 7.58-7.61 (m, 2H). ESI-MS m/e=421 (M+).

後処理

  1. stirringthe reaction mixture was stirred an additional 15 hours at room temperature
  2. customa precipitate formed which
  3. customa solid separated which
  4. customwas removed by filtration
  5. customThe filtrate was evaporated in vacuo
  6. customthe residue was purified on a silica gel flash chromatography column
  7. washeluted with 5% EtOAc-CHCl3
  8. customCombination of the purified fractions and evaporation in vacuo

出典と根拠

ORDレコード
ord-9ef77bcb1cd04af7af073a41481701ba
出典データセット
uspto-grants-1996_10
特許番号
US05565485

反応ノート

読み込み中…