Hydrochloric Acid → Ammonia

HRID 865791

反応式

HRID 865791 の反応式
[P:1]([O:5][C:6]1[CH:17]=[CH:16][C:9]([CH2:10][C@@H:11]([C:13]([OH:15])=[O:14])[NH2:12])=[CH:8][CH:7]=1)([OH:4])([OH:3])=[O:2].Cl>O1CCCC1>[P:1]([O:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:10][C@@H:11]([C:13]([OH:15])=[O:14])[NH2:12])=[CH:16][CH:17]=1)([OH:3])([OH:4])=[O:2].[NH3:12]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 30819Phospho-L-tyrosine

生成物 2

HCID 222AmmoniaHCID 30819Phospho-L-tyrosine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The tyrosine phosphate derivative VIII when treated with a mixture of 0.1M hydrochloric acid and tetrahydrofuran (1:1) at room temperature for 3 hours gave less than 5% loss of the phosphate group. Treatment of compound VIII with concentrated ammonia in a sealed tube for 5 hours at 60° C. gave rise to complete removal of both 2-cyanoethyl groups with only a trace of loss of phosphate.

後処理

  1. customgave less than 5% loss of the phosphate group

出典と根拠

ORDレコード
ord-e6ec16471e054853a786b2a4a401f615
出典データセット
uspto-grants-1996_10
特許番号
US05567811

関連ノート

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