4-Bromodiphenyl Ether → 1-(4-Phenoxyphenyl)prop-2-en-1-ol

温度

0 °C

tert-Butyllithium (24.5 mL, 1.7M in pentane, 42.2 mmol) was added dropwise over 30 min to a solution of 4-bromodiphenyl ether (5.00 g, 20.1 mmol) in THF (50 mL) at -78° C. under argon. The cooling bath was removed and the bright yellow reaction mixture was warmed to 0° C. over 20 min. The reaction was stirred at 0° C. for 30 min, at which time a tan-colored solution developed. Freshly distilled acrolein (1.6 mL, 24 mmol) was added dropwise over 5 min. The colorless reaction mixture was stirred at 0° C. for 15 min, then quenched by addition of saturated NH4Cl (10 mL). The mixture was diluted with diethyl ether (200 mL) and the organic layer was washed with water (20 mL) and brine (50 mL), then dried over MgSO4. Evaporation gave a crude oil which was purified by flash chromatography on silica gel (400 g) eluted with a step gradient of 10:90 EtOAc/hexane to 15:85 EtOAc/hexane to 20:80 EtOAc/hexane to provide title compound (3.31 g, 73%) as a colorless oil.

1. customThe cooling bath was removed
2. stirringThe colorless reaction mixture was stirred at 0° C. for 15 min
3. customquenched by addition of saturated NH4Cl (10 mL)
4. additionThe mixture was diluted with diethyl ether (200 mL)
5. washthe organic layer was washed with water (20 mL) and brine (50 mL)
6. dry with materialdried over MgSO4
7. customEvaporation
8. customgave a crude oil which
9. customwas purified by flash chromatography on silica gel (400 g)
10. washeluted with a step gradient of 10:90 EtOAc/hexane to 15:85 EtOAc/hexane to 20:80 EtOAc/hexane

ORDレコード

ord-68936d09f9624790aeab8864ebd585c1

出典データセット

uspto-grants-1996_10

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05567841