Hydrogen Bromide → 2-(Bromomethyl)-1,3-dimethoxybenzene

HRID 866057

反応式

HRID 866057 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH2:11]O.[Cl-].[Na+].[BrH:15]>C(OCC)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[C:4]=1[CH2:11][Br:15]

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 5234Sodium ChlorideHCID 2776839(2,6-Dimethoxyphenyl)methanol

生成物 1

HCID 155569582-(Bromomethyl)-1,3-dimethoxybenzene

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

After a mixture of 5.7 grams (0.034 mole) of 2,6-dimethoxyphenylmethanol in 40 mL of concentrated hydrobromic acid was stirred at ambient temperature for about one hour, the reaction mixture was taken up in diethyl ether. Solid sodium chloride was added to the mixture to obtain a phase separation. The organic layer was separated and concentrated under reduced pressure, yielding about 4.7 grams of 2,6-dimethoxyphenylmethyl bromide. This compound was used immediately in the next reaction.

後処理

  1. customto obtain
  2. customa phase separation
  3. customThe organic layer was separated
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-7323ba6f5da0405a87601d1bbdbdb171
出典データセット
uspto-grants-1996_10
特許番号
US05569664

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