Dimethyl Sulfoxide → Ethanediamide, N1,N2-bis(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-

HRID 866526

反応式

HRID 866526 の反応式
[C:1]1(=[O:11])O[C:4](=[O:5])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[C:12]([NH:18][NH2:19])(=[O:17])[C:13]([NH:15][NH2:16])=[O:14].CS(C)=O.[OH2:24]>C1(C)C=CC=CC=1>[C:4]1(=[O:5])[N:16]([NH:15][C:13]([C:12]([NH:18][N:19]2[C:1](=[O:11])[C:2]3=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]3[C:4]2=[O:5])=[O:17])=[O:14])[C:1](=[O:24])[C:2]2=[CH:10][CH:9]=[CH:8][CH:7]=[C:3]12

参加物

6

反応物 4

HCID 679Dimethyl SulfoxideHCID 962WaterHCID 6811Phthalic AnhydrideHCID 13826Oxalic acid, dihydrazide

生成物 1

HCID 113193Ethanediamide, N1,N2-bis(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Two moles of phthalic anhydride (296 g.) and one mole of oxalic dihydrazide (118 g.) in 500 ml. dimethyl sulfoxide and 750 ml. toluene were heated at reflux until two moles of water were removed (about 2 hours). The mixture was cooled and filtered. After washing with benzene, the white product was dried to constant weight at 50° C giving an essentially quantitative yield of N,N'bis(phthalimido)oxamide #-# dimethyl sulfoxide 1:2 complex.

後処理

  1. customwere removed (about 2 hours)
  2. temperatureThe mixture was cooled
  3. filtrationfiltered
  4. washAfter washing with benzene
  5. customthe white product was dried to constant weight at 50° C

出典と根拠

ORDレコード
ord-6df4c634f5fb4287861990b6ed1ce0ee
出典データセット
uspto-grants-1978_07
特許番号
US04100132

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