Triethylamine → 1-(3,3-Dimethylcyclohexyl)ethanone

HRID 867150

反応式

HRID 867150 の反応式
[C:1]([CH:4]1[CH2:9][CH2:8][CH2:7][C:6]([CH3:11])([CH3:10])[CH2:5]1)(=[O:3])[CH3:2].[OH-].[Na+].[CH2:14](Cl)[C:15](=[CH2:17])[CH3:16].C(N(CC)CC)C>O>[C:1]([CH:4]1[CH2:9][CH2:8][CH2:7][C:6]([CH3:11])([CH3:10])[CH2:5]1)(=[O:3])[CH3:2].[C:1]([C:4]1([CH2:16][C:15]([CH3:17])=[CH2:14])[CH2:9][CH2:8][CH2:7][C:6]([CH3:11])([CH3:10])[CH2:5]1)(=[O:3])[CH3:2].[CH3:10][C:6]1([CH3:11])[CH2:7][CH2:8][CH2:9][CH:4]([C:1](=[O:3])[CH2:2][CH2:16][C:15]([CH3:17])=[CH2:14])[CH2:5]1

参加物

8

反応物 4

HCID 8471TriethylamineHCID 112413-Chloro-2-methyl-1-propeneHCID 14798Sodium HydroxideHCID 913881-(3,3-Dimethylcyclohexyl)ethanone

生成物 3

HCID 913881-(3,3-Dimethylcyclohexyl)ethanoneHCID 203846051-Acetyl-3,3-dimethyl-1-(2-methyl-2-propenyl)cyclohexaneHCID 203846063,3-Dimethyl-1-(4-methyl-4-pentenoyl)cyclohexane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1-acetyl-3,3-dimethylcyclohexane (156 grams, 1 mole), sodium hydroxide (60 grams, 1.5 moles), methallyl chloride (135 grams, 1.5 moles) and triethylamine (10 grams) is stirred and heated at 80°-84° C. for 12 hours. The reaction mass is cooled to room temperature. Water is added with stirring, and the aqueous layer is discarded. The organic layer is distilled to afford 1-acetyl-3,3-dimethylcyclohexane (62.4 gm), 1-acetyl-3,3-dimethyl-1-(2-methyl-2-propenyl) cyclohexane (80 gm) (NMR spectrum, FIG. 1; IR spectrum, FIG. 2) and 3,3-dimethyl-1-(4-methyl-4-pentenoyl) cyclohexane (8 gm).

後処理

  1. temperatureheated at 80°-84° C. for 12 hours
  2. stirringwith stirring
  3. distillationThe organic layer is distilled

出典と根拠

ORDレコード
ord-c7e174b19a0f43cc891b8db22674b2d8
出典データセット
uspto-grants-1978_07
特許番号
US04102928

関連ノート

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