Piperidine → HCID 178426457、化合物

HRID 867340ノート

反応式

HRID 867340 の反応式
C1CCNCC1.Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br>CS(C)=O.O=C(O)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1.O=P([O-])([O-])[O-].[Cu][I].[K+].[K+].[K+]>Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1N1CCCCC1

参加物

7

反応物 2

HCID 8082PiperidineHCID 193962Etravirine

生成物 1

HCID 178426457HCID 178426457、化合物収率 0%

試薬・触媒・溶媒 4

HCID 62657Potassium Phosphate, Tribasic試薬HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒HCID 1188645142-[3,5-Bis(trifluoromethyl)anilino]-2-oxo-acetic acid触媒HCID 679Dimethyl Sulfoxide溶媒2 回

反応条件

温度
80 °C

後処理

  1. additionThe reaction vials were then cooled to r.t. and diluted with 100 μL of 5% AcOH in DMSO, containing 1,3,5-trimethoxybenzene (0.005M) and were shaken vigorously.
  2. aliquot25 microliter of resulting solution is taken
  3. additionTo the 25 microliter aliquot 700 microliter of MeCN was added prior to UPLC-MS Analysis

出典と根拠

ORDレコード
ord-e74c70aae3f845fd9b4800faef593473
出典データセット
Figure 4 from Chemistry informer libraries
元リンク
出典を表示

反応ノート

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