2-Pyridineethanamine → 1,8,8-Trimethyl-3-[2-(2-pyridinyl)ethyl]-3-azabicyclo[3.2.1]octane-2,4-dione

HRID 867944

反応式

HRID 867944 の反応式
[C:1]1(=[O:13])[O:10][C:8](=O)[CH:7]2[CH2:11][CH2:12][C:2]1([C:4]2([CH3:6])[CH3:5])[CH3:3].[NH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>N1C=CC=CC=1>[CH3:3][C:2]12[C:4]([CH3:5])([CH3:6])[CH:7]([CH2:11][CH2:12]1)[C:8](=[O:10])[N:14]([CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)[C:1]2=[O:13]

参加物

4

反応物 2

HCID 759192-PyridineethanamineHCID 948341,8,8-Trimethyl-3-oxabicyclo[3.2.1]octane-2,4-dione

生成物 1

HCID 142350661,8,8-Trimethyl-3-[2-(2-pyridinyl)ethyl]-3-azabicyclo[3.2.1]octane-2,4-dione

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of (-) camphoric anhydride 5 g (0.029 mol), 2-(2-aminoethyl)pyridine 3.6 (0.03 mol) and 50 ml of pyridine was refluxed overnight. The solvent is removed under reduced pressure and the remaining oil boiled in 20 ml of ethanol and allowed to cool.

後処理

  1. temperaturewas refluxed overnight
  2. customThe solvent is removed under reduced pressure
  3. temperatureto cool

出典と根拠

ORDレコード
ord-14d27eb0342e4f14801d1f2da1572273
出典データセット
uspto-grants-1988_10
特許番号
US04777254

関連ノート

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