Dimethylamine → HCID 2762435、化合物

HRID 868838ノート

反応式

HRID 868838 の反応式
[CH3:1][NH:2][CH3:3].[CH2:4]=O.[CH3:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[CH:10][NH:11]2.[OH-].[Na+]>C(O)(=O)C>[CH3:1][N:2]([CH3:4])[CH2:3][C:9]1[C:8]2[C:12](=[CH:13][CH:14]=[CH:15][C:7]=2[CH3:6])[NH:11][CH:10]=1

参加物

6

反応物 4

HCID 674DimethylamineHCID 712FormaldehydeHCID 14798Sodium HydroxideHCID 852824-Methylindole

生成物 1

HCID 2762435HCID 2762435、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a chilled solution of dimethyl amine (30 mL, 40% in water, 120 mmol) and formalin (13 mL, 37% in water, 84 mmol) in glacial acetic acid (30 mL) is added 4-methyl indole (21 g, 165 mmol) at 0° C. The reaction is warmed to room temperature and stirred for 3 hours. The reaction mixture is brought to pH 12 by addition of 50% NaOH and ice, and the product extracted with methylene chloride. The organic layers are dried over Na2SO4 filtered and evaporated in vacuo to give the title compound that is used without further purification (33 g, 162 mmol, 98%) LC/MS (M++1): 205.7.

後処理

  1. extractionthe product extracted with methylene chloride
  2. dry with materialThe organic layers are dried over Na2SO4
  3. filtrationfiltered
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-5e9430295ee14861a44a981cdbca0c98
出典データセット
uspto-grants-2015_03
特許番号
US08969348B2

反応ノート

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