Methyl iodide → HCID 86665673、化合物

HRID 868839ノート

反応式

HRID 868839 の反応式
[CH3:1][N:2]([CH3:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[CH3:13])[NH:6][CH:5]=1.[CH3:15][I:16]>C(#N)C>[I-:16].[CH3:1][N+:2]([CH3:15])([CH3:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[CH3:13])[NH:6][CH:5]=1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 2762435HCID 2762435、化合物

生成物 1

HCID 86665673HCID 86665673、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

Dimethyl-(4-methyl-1H-indol-3-ylmethyl)-amine (20 g, 98 mmol) is suspended in acetonitrile, and warmed to completely dissolve the material. The reaction is cooled to room temperature and then methyl iodide (9.1 mL, 147 mmol) is added dropwise to the reaction. The reaction is covered with foil and then stirred at room temperature overnight. The reaction is then filtered and the filtrate evaporate in vacuo to give an oil that is taken up in acetonitrile. The white solid is then triturated with acetonitrile and ether, and combined with the original solid to give the title compound that is used without further purification (30 g, 87 mmol, 88%) LC/MS (M++1): 347.

後処理

  1. temperaturewarmed
  2. dissolutionto completely dissolve the material
  3. filtrationThe reaction is then filtered
  4. customthe filtrate evaporate in vacuo
  5. customto give an oil that
  6. customThe white solid is then triturated with acetonitrile and ether

出典と根拠

ORDレコード
ord-506eb8760e4b4118a2a54488280a975a
出典データセット
uspto-grants-2015_03
特許番号
US08969348B2

反応ノート

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