Acetonitrile → 2-[3-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-1,2,3,4-tetrahydroisoquinoline

HRID 8691

反応式

HRID 8691 の反応式
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:12]2[C:16]3[S:17][CH:18]=[CH:19][C:15]=3[O:14][N:13]=2)[CH:9]=[CH:10][CH:11]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:26]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH2:28][NH:27]1.C(#N)C>C(Cl)Cl>[O:14]1[C:15]2[CH:19]=[CH:18][S:17][C:16]=2[C:12]([C:8]2[CH:7]=[C:6]([CH:11]=[CH:10][CH:9]=2)[O:5][CH2:4][CH2:3][CH2:2][N:27]2[CH2:28][CH2:29][C:30]3[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=3)[CH2:26]2)=[N:13]1

参加物

6

反応物 4

HCID 6342AcetonitrileHCID 70461,2,3,4-TetrahydroisoquinolineHCID 11430Potassium CarbonateHCID 219835593-[3-(3-Bromo-propoxy)phenyl]-thieno[2,3-d]isoxazole

生成物 1

HCID 219835682-[3-(3-Thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-1,2,3,4-tetrahydroisoquinoline

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title compound is prepared from 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 1,2,3,4-tetrahydroisoquinoline and acetonitrile essentially as described above in example 48 except that the crude product is dissolve in DCM and purified by using a step gradient of 50% ethyl acetate in heptane, to 100% ethyl acetate. Purity by LC/MS (APCI)=96%, [M+H]+=391.

後処理

  1. custompurified

出典と根拠

ORDレコード
ord-f77827b82f184b44a8fecc9f72a1fa72
出典データセット
uspto-grants-2006_08
特許番号
US07091199B1

関連ノート

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