HCID 21914755、化合物 → HCID 21914786、化合物

HRID 869397ノート

反応式

HRID 869397 の反応式
[C:1]([NH:6][C:7]1[S:8][CH:9]=[C:10]([CH2:12][OH:13])[N:11]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3]>C1COCC1.O=[Mn]=O>[CH:12]([C:10]1[N:11]=[C:7]([NH:6][C:1](=[O:5])[CH:2]([CH3:3])[CH3:4])[S:8][CH:9]=1)=[O:13]

参加物

4

反応物 1

HCID 21914755HCID 21914755、化合物

生成物 1

HCID 21914786HCID 21914786、化合物収率 50.4%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 8028Tetrahydrofuran溶媒

実験手順

11C (0.5 g, 2.5 mmol) was dissolved in THF (10 mL). To the solution at room temperature was added activated MnO2 (1.74 g, 20 mmol). The reaction mixture was refluxed overnight, then filtered. The filtrate was concentrated and dried to give a crude product 11D (0.25 g, 50% yield).

後処理

  1. temperatureThe reaction mixture was refluxed overnight
  2. filtrationfiltered
  3. concentrationThe filtrate was concentrated
  4. customdried

出典と根拠

ORDレコード
ord-9f604a989b0f492380e5dab8441b0aab
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

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