Sodium Hydroxide → HCID 136348391、化合物

HRID 869402ノート

反応式

HRID 869402 の反応式
[Br:1][C:2]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([OH:11])[C:3]=1[CH:4]=O.Cl.[NH2:13][OH:14].[OH-].[Na+]>CCO>[Br:1][C:2]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([OH:11])[C:3]=1[CH:4]=[N:13][OH:14]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 156059702-Bromo-3,6-dihydroxybenzaldehyde

生成物 1

HCID 136348391HCID 136348391、化合物収率 84.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a mixture of 2-bromo-3,6-dihydroxy-benzaldehyde (12A) (50 g, 0.23 mol) and hydroxylamine hydrochloride (19.2 g, 0.28 mol) was added 95% EtOH (500 mL), followed by NaOH (13.8 g, 0.345 mol). The reaction mixture was stirred at room temperature for 2 hours, then extracted with ethyl acetate and concentrated to give 2-bromo-3,6-dihydroxy-benzaldehyde oxime (12B) (45 g, 84.1% yield) as a solid.

後処理

  1. extractionextracted with ethyl acetate
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-670e5e37d68044959b9b8a514109aa0e
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

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