Water → HCID 86722252、化合物

HRID 869407ノート

反応式

HRID 869407 の反応式
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([Br:15])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[F-].[Cs+].[CH3:18]I.O>C1COCC1>[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:18])=[C:10]([Br:15])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2]

参加物

6

反応物 4

HCID 962WaterHCID 6328Methyl iodideHCID 25953Cesium fluorideHCID 86722251HCID 86722251、化合物

生成物 1

HCID 86722252HCID 86722252、化合物収率 42.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a mixture of 12F (5.6 g, 0.020 mol) and CsF (9.5 g, 0.0625 mol) in THF (20 mL) was added MeI (2.9 g) dropwise at room temperature. The reaction mixture was stirred at room temperature for 1 hour, then added dropwise into water. The solids were precipitated out dissolved in ethyl acetate and purified by column chromatography on silica gel to give 12G (2.4 g, 40.7% yield).

後処理

  1. customThe solids were precipitated
  2. dissolutionout dissolved in ethyl acetate
  3. custompurified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-f436c9b2248b4f75b8fb50f49763a398
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

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