Water → HCID 86722255、化合物

HRID 869409ノート

反応式

HRID 869409 の反応式
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Br:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17]([C:20]1[S:21][C:22]([CH:25]=O)=[CH:23][N:24]=1)([CH3:19])[CH3:18].[OH-].[Na+].O>C1COCC1>[NH2:9][C:8]1[C:7]2[C:10]([Br:16])=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:6]=2[O:5][C:4]=1[C:1](=[O:3])/[CH:2]=[CH:25]/[C:22]1[S:21][C:20]([CH:17]([CH3:19])[CH3:18])=[N:24][CH:23]=1

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 450838485-Thiazolecarboxaldehyde, 2-(1-methylethyl)- (9CI)HCID 86722252HCID 86722252、化合物

生成物 1

HCID 86722255HCID 86722255、化合物収率 63.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

A mixture of 12G (1.5 g, 5.2 mmol), 2-isopropyl-thiazole-5-carbaldehyde (1.2 g, 7.7 mmol) in THF (20 mL) was cooled to 0° C. To the mixture was added NaOH (1.5 g), then stirred at room temperature overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 14A (1.4 g, 62.9% yield).

後処理

  1. customthe reaction
  2. filtrationThe precipitated solids were collected by filtration

出典と根拠

ORDレコード
ord-bb860ab867aa427797ee077a286a45ca
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

読み込み中…