Water → HCID 86722262、化合物

HRID 869416ノート

反応式

HRID 869416 の反応式
[C:1]([C:4]1[O:5][C:6]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([Br:16])[C:7]=2[C:8]=1[NH2:9])(=[O:3])[CH3:2].[CH:17]([C:19]1[N:20]=[C:21]([NH:24][C:25](=[O:29])[CH:26]([CH3:28])[CH3:27])[S:22][CH:23]=1)=O.[OH-].[Na+].O>C1COCC1>[NH2:9][C:8]1[C:7]2[C:10]([Br:16])=[C:11]([O:14][CH3:15])[CH:12]=[CH:13][C:6]=2[O:5][C:4]=1[C:1](=[O:3])[CH:2]=[CH:17][C:19]1[N:20]=[C:21]([NH:24][C:25](=[O:29])[CH:26]([CH3:27])[CH3:28])[S:22][CH:23]=1

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 21914786HCID 21914786、化合物HCID 86722252HCID 86722252、化合物

生成物 1

HCID 86722262HCID 86722262、化合物収率 61.5%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

A mixture of 12G (2 g, 7 mmol), 11D (2.8 g, 14.5 mmol) in THF (20 mL) was cooled to 0° C. To the mixture was added NaOH (2 g). The reaction mixture was reacted at room temperature overnight. TLC monitored the reaction. After reaction completed, the reaction mixture was added dropwise into water. The precipitated solids were collected by filtration to give 16A (2 g, 61% yield).

後処理

  1. customThe reaction mixture was reacted at room temperature overnight
  2. customthe reaction
  3. customAfter reaction
  4. filtrationThe precipitated solids were collected by filtration

出典と根拠

ORDレコード
ord-57a89331ccec49479c9f21fc73896ff6
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

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