HCID 86722263、化合物 → HCID 178488263、化合物

HRID 869418ノート

反応式

HRID 869418 の反応式
[Br:1][C:2]1[C:7]2[C:8]3[NH:9][CH:10]([C:16]4[N:17]=[C:18]([NH:21][C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])[S:19][CH:20]=4)[CH2:11][C:12](=[O:15])[C:13]=3[O:14][C:6]=2[CH:5]=[CH:4][C:3]=1[O:27][CH3:28]>C1COCC1.O=[Mn]=O>[OH:15][C:12]1[CH:11]=[C:10]([C:16]2[N:17]=[C:18]([NH:21][C:22](=[O:26])[CH:23]([CH3:25])[CH3:24])[S:19][CH:20]=2)[N:9]=[C:8]2[C:7]3[C:2]([Br:1])=[C:3]([O:27][CH3:28])[CH:4]=[CH:5][C:6]=3[O:14][C:13]=12

参加物

4

反応物 1

HCID 86722263HCID 86722263、化合物

生成物 1

HCID 178488263HCID 178488263、化合物収率 65.8%

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
110 °C

実験手順

A mixture of 16B (1.1 g, 2.3 mmol) and MnO2 (6 g) in THF (20 mL) was heated to 110° C. and reacted overnight. TLC monitored the reaction. After the reaction completed, the reaction mixture was filtered and the filtrate was concentrated to give 16C (0.7 g, 63.9% yield).

後処理

  1. customreacted overnight
  2. customthe reaction
  3. filtrationthe reaction mixture was filtered
  4. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-5528cf74dfc54dfeac025641fb32599e
出典データセット
uspto-grants-2015_03
特許番号
US08969373B2

反応ノート

読み込み中…