Ammonium formate → 2-Methoxy-4-(2-pyrrolidin-1-ylethyl)phenylamine
反応式
C([O-])=O.[NH4+].[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH2:16][CH2:17][N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)[CH:10]=[CH:11][C:12]=1[N+:13]([O-])=O>CO.[Pd]>[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH2:16][CH2:17][N:18]2[CH2:22][CH2:21][CH2:20][CH2:19]2)[CH:10]=[CH:11][C:12]=1[NH2:13]参加物
5
実験手順
0.41 g of palladium-on-charcoal and 4.1 g (64.32 mmol) of ammonium formate are added to a solution of 3.2 g (12.86 mmol) of the product prepared in step 24.2 in 120 mL of methanol, under argon, and the mixture is refluxed for 2 hours. After filtration, the filtrate is concentrated to dryness to give 2.6 g of the expected product in the form of a light-brown solid, which is used as obtained in the following step. Yield=92%.
後処理
- temperaturethe mixture is refluxed for 2 hours
- filtrationAfter filtration
- concentrationthe filtrate is concentrated to dryness
出典と根拠
- ORDレコード
- ord-0d0a280b9d3244499faa01336aa8a3ee
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08975250B2
反応ノート
読み込み中…