Hydrochloric Acid → HCID 67172452、化合物
反応式
[N:1]1([CH2:6][C:7]2[S:11][C:10]([C:12]([O:14]CC)=[O:13])=[N:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[Li+].[OH-].Cl>C1COCC1.CO>[N:1]1([CH2:6][C:7]2[S:11][C:10]([C:12]([OH:14])=[O:13])=[N:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1参加物
6
実験手順
A solution of ethyl 5-((1H-imidazol-1-yl)methyl)thiazole-2-carboxylate (143 mg, 0.60 mmol) and 1 M LiOH solution (1.2 ml, 1.2 mmol) in THF (2 ml) and MeOH (1 ml) was stirred at RT for 1.5 h. Some 1 M HCl was added until pH of the mixture was about 8. Solvents were evaporated and thus obtained crude product was used as such in the next synthesis step. 1H-NMR (400 MHz; d6-DMSO): δ 5.28 (s, 2H), 6.92 (s, 1H), 7.22 (s, 1H), 7.54 (s, 1H), 7.79 (s, 1H).
後処理
- customSolvents were evaporated
- customthus obtained crude product
- customsuch in the next synthesis step
出典と根拠
- ORDレコード
- ord-1acf1ae059e74c72a8d1944f35d1f84d
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08975254B2
反応ノート
読み込み中…