Oxalyl chloride → Quinoline-6-carbonyl chloride

HRID 876790

反応式

HRID 876790 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=O)=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C(Cl)(=O)C([Cl:17])=O>C(Cl)Cl.CN(C=O)C>[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([Cl:17])=[O:13])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 825716-Quinolinecarboxylic acid

生成物 1

HCID 12391963Quinoline-6-carbonyl chloride収率 99.8%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

To a mixture of quinoline-6-carboxylic acid (0-1) (2.0 g, 11.5 mmol) in CH2Cl2 (250 mL) was added 3 drops of DMF at 0° C., followed by oxalyl chloride (7.3 g, 57.5 mmol) dropwise. The resulting reaction was stirred at room temperature overnight, and then concentrated to afford the title compound (2.2 g).

後処理

  1. customThe resulting reaction
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-a32c4c7516d54483ba9baf7d0922695d
出典データセット
uspto-grants-2015_03
特許番号
US08987269B2

関連ノート

読み込み中…